Effects of anti-protozoal drugs and histopathological studies on trypanosome species
Identifieur interne : 002275 ( Main/Exploration ); précédent : 002274; suivant : 002276Effects of anti-protozoal drugs and histopathological studies on trypanosome species
Auteurs : Jamiu A. Ogunbanwo [Nigeria] ; Dennis E. Agbonlahor [Nigeria] ; A. Adamu [Nigeria] ; P. Dalyop [Nigeria] ; Stephen O. Elesha [Nigeria] ; A. F Fagbenro-Beyioku [Nigeria]Source :
- FEMS Immunology and Medical Microbiology [ 0928-8244 ] ; 2001.
English descriptors
- Teeft :
- Abraka, Abraka strain, African trypanosomiasis, Bassa, Bassa strain, Benzoylmetronidazole, Binocular microscope, Brucei, Brucei brucei, Brucei brucei bassa strain, Brucei gambiense, Brucei gambiense abraka strain, Central vein, Chloroquine, Chloroquine phosphate, Congolense, Congolense zaria strain, Control group, Control rats, Elsevier science, Fems, Fems immunology, Femsim, Gambiense, Halofantrine, Halofantrine hydrochloride, Histopathological, Immunology, Lagos, Medical microbiology, Microbiology, Motile, Motile trypanosomes, Motility, Multiple doses, Nigeria, Nigerian institute, Ogunbanwo, Parasitaemia, Parasite, Parasitol, Pathological changes, Plateau state, Present study, Psgm, Pyrimethamine, Rat, Same observation, Same trypanosomes, Survival period, Test groups, Time duration, Trypanosoma, Trypanosoma brucei brucei, Trypanosome species, Trypanosomes, Trypanosomiasis, Trypanosomicidal, Trypanosomostatic, Tubular necrosis, Vivo, Vivo studies, Xxxx, Zaria, Zaria strain.
Abstract
Abstract: The trypanosomostatic and trypanosomicidal effects of four anti-protozoal drugs, namely halofantrine hydrochloride, chloroquine phosphate, benzoylmetronidazole and pyrimethamine, on species of trypanosomes, viz. Trypanosoma brucei brucei (MBOS/NG/94/NITR) Bassa strain, T. congolense (MBOS/NG/93/NVRI) Zaria strain and T. brucei gambiense (MHOM/NG/92/NITR) Abraka strain, were investigated. In vitro and in vivo studies on these drugs vis-a-vis the parasites were carried out. The histopathological changes in organs and tissues of experimentally infected rats were also studied. Results from the in vitro studies indicated that halofantrine hydrochloride, chloroquine phosphate, benzoylmetronidazole and pyrimethamine appeared to be effective trypanosomicidal agents against T. brucei brucei (Bassa strain), T. congolense (Zaria strain) and T. brucei gambiense (Abraka strain). The in vivo studies showed that these drugs were sub-curative by prolonging the survival period of the trypanosome-infected rats, but not necessarily curing the infection. Histopathological findings indicated inflammatory reactions characterised by infiltration to variable degrees in the majority of tissues, mostly in the lungs and liver. The most consistent lesions were interstitial pneumonia, multifocal necrosis and oedema. Pathological findings showed the T. brucei brucei and T. brucei gambiense strains studied to be both intravascular and extravascular parasites. These results suggest that halofantrine hydrochloride, chloroquine phosphate, benzoylmetronidazole and pyrimethamine could be used as supportive, suppressive and/or synergistic/additive drugs in the treatment of African trypanosomiasis. Their effects on species of trypanosomes have been studied and are reported for the first time.
Url:
DOI: 10.1016/S0928-8244(00)00229-7
Affiliations:
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Adamu</name><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Nigerian Institute for Trypanosomiasis Research, Vom, Plateau State</wicri:regionArea><wicri:noRegion>Plateau State</wicri:noRegion></affiliation></author><author><name sortKey="Dalyop, P" sort="Dalyop, P" uniqKey="Dalyop P" first="P" last="Dalyop">P. Dalyop</name><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Nigerian Institute for Trypanosomiasis Research, Vom, Plateau State</wicri:regionArea><wicri:noRegion>Plateau State</wicri:noRegion></affiliation></author><author><name sortKey="Elesha, Stephen O" sort="Elesha, Stephen O" uniqKey="Elesha S" first="Stephen O" last="Elesha">Stephen O. Elesha</name><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>College of Medicine, University of Lagos, Lagos</wicri:regionArea><wicri:noRegion>Lagos</wicri:noRegion></affiliation></author><author><name sortKey="Fagbenro Beyioku, A F" sort="Fagbenro Beyioku, A F" uniqKey="Fagbenro Beyioku A" first="A. F" last="Fagbenro-Beyioku">A. F Fagbenro-Beyioku</name><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>College of Medicine, University of Lagos, Lagos</wicri:regionArea><wicri:noRegion>Lagos</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">FEMS Immunology and Medical Microbiology</title><title level="j" type="abbrev">FEMSIM</title><idno type="ISSN">0928-8244</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">30</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="73">73</biblScope><biblScope unit="page" to="83">83</biblScope></imprint><idno type="ISSN">0928-8244</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0928-8244</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abraka</term><term>Abraka strain</term><term>African trypanosomiasis</term><term>Bassa</term><term>Bassa strain</term><term>Benzoylmetronidazole</term><term>Binocular microscope</term><term>Brucei</term><term>Brucei brucei</term><term>Brucei brucei bassa strain</term><term>Brucei gambiense</term><term>Brucei gambiense abraka strain</term><term>Central vein</term><term>Chloroquine</term><term>Chloroquine phosphate</term><term>Congolense</term><term>Congolense zaria strain</term><term>Control group</term><term>Control rats</term><term>Elsevier science</term><term>Fems</term><term>Fems immunology</term><term>Femsim</term><term>Gambiense</term><term>Halofantrine</term><term>Halofantrine hydrochloride</term><term>Histopathological</term><term>Immunology</term><term>Lagos</term><term>Medical microbiology</term><term>Microbiology</term><term>Motile</term><term>Motile trypanosomes</term><term>Motility</term><term>Multiple doses</term><term>Nigeria</term><term>Nigerian institute</term><term>Ogunbanwo</term><term>Parasitaemia</term><term>Parasite</term><term>Parasitol</term><term>Pathological changes</term><term>Plateau state</term><term>Present study</term><term>Psgm</term><term>Pyrimethamine</term><term>Rat</term><term>Same observation</term><term>Same trypanosomes</term><term>Survival period</term><term>Test groups</term><term>Time duration</term><term>Trypanosoma</term><term>Trypanosoma brucei brucei</term><term>Trypanosome species</term><term>Trypanosomes</term><term>Trypanosomiasis</term><term>Trypanosomicidal</term><term>Trypanosomostatic</term><term>Tubular necrosis</term><term>Vivo</term><term>Vivo studies</term><term>Xxxx</term><term>Zaria</term><term>Zaria strain</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The trypanosomostatic and trypanosomicidal effects of four anti-protozoal drugs, namely halofantrine hydrochloride, chloroquine phosphate, benzoylmetronidazole and pyrimethamine, on species of trypanosomes, viz. Trypanosoma brucei brucei (MBOS/NG/94/NITR) Bassa strain, T. congolense (MBOS/NG/93/NVRI) Zaria strain and T. brucei gambiense (MHOM/NG/92/NITR) Abraka strain, were investigated. In vitro and in vivo studies on these drugs vis-a-vis the parasites were carried out. The histopathological changes in organs and tissues of experimentally infected rats were also studied. Results from the in vitro studies indicated that halofantrine hydrochloride, chloroquine phosphate, benzoylmetronidazole and pyrimethamine appeared to be effective trypanosomicidal agents against T. brucei brucei (Bassa strain), T. congolense (Zaria strain) and T. brucei gambiense (Abraka strain). The in vivo studies showed that these drugs were sub-curative by prolonging the survival period of the trypanosome-infected rats, but not necessarily curing the infection. Histopathological findings indicated inflammatory reactions characterised by infiltration to variable degrees in the majority of tissues, mostly in the lungs and liver. The most consistent lesions were interstitial pneumonia, multifocal necrosis and oedema. Pathological findings showed the T. brucei brucei and T. brucei gambiense strains studied to be both intravascular and extravascular parasites. These results suggest that halofantrine hydrochloride, chloroquine phosphate, benzoylmetronidazole and pyrimethamine could be used as supportive, suppressive and/or synergistic/additive drugs in the treatment of African trypanosomiasis. Their effects on species of trypanosomes have been studied and are reported for the first time.</div></front></TEI><affiliations><list><country><li>Nigeria</li></country></list><tree><country name="Nigeria"><noRegion><name sortKey="Ogunbanwo, Jamiu A" sort="Ogunbanwo, Jamiu A" uniqKey="Ogunbanwo J" first="Jamiu A" last="Ogunbanwo">Jamiu A. Ogunbanwo</name></noRegion><name sortKey="Adamu, A" sort="Adamu, A" uniqKey="Adamu A" first="A" last="Adamu">A. Adamu</name><name sortKey="Agbonlahor, Dennis E" sort="Agbonlahor, Dennis E" uniqKey="Agbonlahor D" first="Dennis E" last="Agbonlahor">Dennis E. Agbonlahor</name><name sortKey="Dalyop, P" sort="Dalyop, P" uniqKey="Dalyop P" first="P" last="Dalyop">P. Dalyop</name><name sortKey="Elesha, Stephen O" sort="Elesha, Stephen O" uniqKey="Elesha S" first="Stephen O" last="Elesha">Stephen O. Elesha</name><name sortKey="Fagbenro Beyioku, A F" sort="Fagbenro Beyioku, A F" uniqKey="Fagbenro Beyioku A" first="A. F" last="Fagbenro-Beyioku">A. F Fagbenro-Beyioku</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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